The traditional occupational safety and health programs of the twentieth century were designed, by and large, to prevent work-related injury, illness, and death in workplaces where hazards usually were recognizable and predictable. In the twenty-first century, scientists and decision-makers have had to develop additional skills and strategies to address another type of hazard: the risks that emergency responders face in the line of duty from unpredictable, uncontrolled conditions encountered in large-scale disasters.