Blood levels of trans–fatty acids (TFAs) in white adults in the U.S. population decreased by 58 percent from 2000 to 2009 according to a Centers for Disease Control and Prevention study published in the Feb. 8 edition of the Journal of the American Medical Association. This is the first time CDC researchers have been able to measure trans fats in human blood.

CDC researchers selected participants from the National Health and Nutrition Examination Survey (NHANES) years 2000 and 2009 to examine trans–fatty acid blood levels before and after the Food and Drug Administration′s 2003 regulation, which took effect in 2006, requiring manufacturers of food and some dietary supplements to list the amount of TFAs on the Nutrition Facts panel of the product label. During this period, some local and state health departments took steps to help consumers reduce their daily consumption by requiring restaurants to limit their use of TFAs in food and increase public awareness campaigns about the health risks associated with TFAs.

“The 58 percent decline shows substantial progress that should help lower the risk of cardiovascular disease in adults,” said Christopher Portier, Ph.D., director of CDC′s National Center for Environmental Health. “Findings from the CDC study demonstrate the effectiveness of these efforts in reducing blood TFAs and highlight that further reductions in the levels of trans fats must remain an important public health goal.”

The current study provides information for white adults only, and additional CDC studies are under way to examine blood TFAs in other adult race/ethnic groups, children, and adolescents, Dr. Portier added.

This research is a part of CDC′s larger National Biomonitoring program, which currently measures more than 450 environmental chemicals and nutritional indicators in people.

Unlike other dietary fats, trans fats are not essential to human health and do not promote good health. Research has indicated that high consumption of trans–fatty acids is linked to cardiovascular disease in part because TFAs increase LDL cholesterol (“bad” cholesterol). Changing to a diet low in TFAs may lower LDL cholesterol levels, thus decreasing the risk for cardiovascular disease.

For more information on CDC′s study: http://jama.ama-assn.org/ External Web Site Icon
For more information on CDC′s work in the National Biomonitoring program: http://www.cdc.gov/nceh/dls/nbp.html

Background on study
CDC studied four major TFAs to provide a reasonable representation of TFAs in blood: elaidic acid, linoelaidic acid, palmitelaidic acid, and vaccenic acid. The study measured TFAs in 229 fasting adults from the 2000 NHANES and 292 from 2009 NHANES.

The study found the overall decrease in trans–fatty acids was 58 percent. For specific trans–fatty acids, decreases were: elaidic acid – 63 percent, linoelaidic acid – 49 percent, palmitelaidic acid – 49 percent, and vaccenic acid – 56 percent.

About NHANES

CDC′s National Health and Nutrition Examination is a cross–sectional survey of the U.S. population weighted to be nationally representative. For this study, researchers used a randomly selected one–half sample of white persons aged 20 years and older from the morning fasting sample from NHANES 2000 and 2009.

About Trans Fats

• The USDA/HHS Dietary Guidelines for Americans 2010 recommend keeping TFA consumption as low as possible, especially by limiting foods that contain synthetic sources of trans fats, such as partially hydrogenated oils, and by limiting other solid fats: www.cnpp.usda.gov/DGAs2010-PolicyDocument.htmExternal Web Site Icon
• TFAs in blood come from synthetic sources in foods, such as partially hydrogenated vegetable oils, and natural sources in foods, such as milk.
• Hydrogenation is used by food manufacturers to make products containing unsaturated fatty acids solid at room temperature and therefore more resistant to becoming spoiled or rancid.
• Trans–fatty acids are produced by grazing animals, and small quantities are therefore found in meat and milk products.
• Since 2006, FDA has required nutrition facts labels to list the amount of trans fats in food products. At restaurants, customers can ask before they order, to know which fats are being used to prepare the food. Many restaurants display nutritional content or can provide it upon request www.fda.gov/Food/ResourcesForYou/Consumers/ucm079609.htmExternal Web Site Icon.

CDC recommends

• Look for the trans fat listing on the Nutrition Facts label. Compare brands and choose the one lowest in trans fat, preferably with no trans fat.
• Replace margarine containing trans fat with unsaturated vegetable oil.
• If you use margarine, choose a soft margarine spread instead of stick margarine. Check your labels to be sure the soft margarine does contain less trans fat. If possible, find one that says zero grams of tran fat.